South Italy/North Italy is an uncommon pairing involving the characters North Italy and South Italy. It is often addressed as "Itacest".
Fan Speculations
Some fans believe that Romano's hatred towards Germany may be because that Italy is around and likes Germany more than him, and others believe that it is because Holy Roman Empire, someone why upset Italy looked like Germany. This is seen when he was so sad when Italy didn't have anything nice to say about him, may be the reason he is rude to his brother. Italy does cares for Romano, shown when he was happy to sleep in the same bed with him. Some fans believe that Italy has a brother complex with Romano or the other way around.
Image
The Italian brothers in a Bamboo Thicket sketch.
North Italy comforting South Italy.