America and North Italy in the anime
Hetalia Axis Powes- Read The Atmosphere (Italy and America)
America/North Italy is a yaoi pairing originating from their interaction in one of the episodes, where America tells Italy that someone told him that he should try to go read the atmosphere. He asks if Italy knows a bookstore selling how to read the atmosphere. Italy responds with "I've been told that before, too. Let's go look for it together!" This is the only time they interact in the anime.
The fanmade game HetaQuest's main characters are America and North Italy, who are both searching on how to read the atmosphere in the beginning of the game.