South Italy/America

South Italy/America is a common Romano pairing found in the fandom. In World Stars, it's revealed that Romano lived in America's place for a while and worked for him. Because of this, Romano knows America quite well, which is shown in one strip in which he and Veneziano prepare food for America.

It is thought of as the same concept as Spamano. America, similarly to Spain, is very cheerful and affectionate, whereas Romano is a tsundere character.

Fans counter that this pairing is possible, the same way America/England or England/America, Spain/Romano and Spain/England are possible, with one character being tsundere and the other being cheerful and affectionate.